The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer
SY Fuchs, VS Spiegelman, KG Suresh Kumar - Oncogene, 2004 - nature.com
SY Fuchs, VS Spiegelman, KG Suresh Kumar
Oncogene, 2004•nature.comBeta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition
subunits for the SCF β-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically
phosphorylated substrates and play a pivotal role in the regulation of cell division and
various signal transduction pathways, which, in turn, are essential for many aspects of
tumorigenesis. We review the functions of the SCF β-TrCP ligases in the light of their
relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP …
subunits for the SCF β-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically
phosphorylated substrates and play a pivotal role in the regulation of cell division and
various signal transduction pathways, which, in turn, are essential for many aspects of
tumorigenesis. We review the functions of the SCF β-TrCP ligases in the light of their
relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP …
Abstract
Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCF β-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCF β-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting β-TrCP as a means of anticancer therapy are also discussed.
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