[HTML][HTML] Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression

B Han, R Mehra, RJ Lonigro, L Wang, K Suleman… - Modern pathology, 2009 - Elsevier
The link between ERG rearrangement and PTEN (phosphatase and tensin homolog deleted
on chromosome 10) deletion is unclear in prostate cancer progression. Using fluorescence
in situ hybridization, we systematically validated the frequency and distribution of ERG and
PTEN aberrations in a cohort of 73 benign prostate tissues, 59 high-grade prostatic
intraepithelial neoplasia (HGPIN) foci, 281 localized prostate cancer and 47 androgen-
independent metastatic prostate cancer patients. Overall, ERG rearrangement was present …