Postoperative hyperoxia (60%) worsens hepatic injury in mice
Q Zangl, A Martignoni, SH Jackson, A Ohta… - …, 2014 - pubs.asahq.org
Background: Liver damage by ischemia and reperfusion injury is a risk factor for morbidity
and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the
postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury
by increasing inspiratory oxygen from 21 to 60% in the postoperative period were
investigated in mice. Methods: Parameters of liver injury were compared after induction of
hepatic ischemia–reperfusion injury, by clamping the left liver lobe for 45 min, and …
and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the
postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury
by increasing inspiratory oxygen from 21 to 60% in the postoperative period were
investigated in mice. Methods: Parameters of liver injury were compared after induction of
hepatic ischemia–reperfusion injury, by clamping the left liver lobe for 45 min, and …