Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
SM Hatfield, M Sitkovsky - Oncoimmunology, 2015 - Taylor & Francis
SM Hatfield, M Sitkovsky
Oncoimmunology, 2015•Taylor & FrancisOxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A
adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This,
in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells.
Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic
value, but only in combination with cancer immunotherapies.
adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This,
in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells.
Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic
value, but only in combination with cancer immunotherapies.
Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies.
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