Preferential expression of the novel alternative isoform I. 3 of hypoxia-inducible factor 1α in activated human T lymphocytes
D Lukashev, M Sitkovsky - Human immunology, 2008 - Elsevier
Hypoxia-inducible factor–1α (HIF-1α) is critical not only in the regulation of oxygen
homeostasis but also in the regulation of innate and adaptive immune systems. We
previously reported that T-cell receptor–mediated activation of T cells in mice leads to the
expression of an alternative isoform of HIF-1α that inhibits activated T cells in a delayed
negative feed-back manner. In this paper, we describe a novel mRNA isoform of human HIF-
1α that is upregulated in peripheral T lymphocytes after T-cell receptor stimulation. This …
homeostasis but also in the regulation of innate and adaptive immune systems. We
previously reported that T-cell receptor–mediated activation of T cells in mice leads to the
expression of an alternative isoform of HIF-1α that inhibits activated T cells in a delayed
negative feed-back manner. In this paper, we describe a novel mRNA isoform of human HIF-
1α that is upregulated in peripheral T lymphocytes after T-cell receptor stimulation. This …