Lessons from the A2A adenosine receptor antagonist–enabled tumor regression and survival in patients with treatment-refractory renal cell cancer

MV Sitkovsky - Cancer Discovery, 2020 - AACR
Cancer Discovery, 2020AACR
In this issue of Cancer Discovery, Fong and colleagues describe the encouraging
observations of tumor regression, disease control, and survival of patients with otherwise
refractory renal cell cancer with progressive disease after treatment with the conceptually
novel oral antagonist of the A2A adenosine receptor (A2AR), ciforadenant. A2AR
antagonists may represent the until now missing but critically important part of more effective
immunotherapies of cancer, because they prevent the inhibition of tumor-reactive T and …
Summary
In this issue of Cancer Discovery, Fong and colleagues describe the encouraging observations of tumor regression, disease control, and survival of patients with otherwise refractory renal cell cancer with progressive disease after treatment with the conceptually novel oral antagonist of the A2A adenosine receptor (A2AR), ciforadenant. A2AR antagonists may represent the until now missing but critically important part of more effective immunotherapies of cancer, because they prevent the inhibition of tumor-reactive T and natural killer cells by blocking the immunosuppressive hypoxia–A2A–adenosinergic signaling, which represents an emerging immunosuppressive hallmark of tumors that are the most resistant to therapies.
See related article by Fong et al., p. 40.
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