[HTML][HTML] Regulation of scavenger receptor class B type I in hamster liver and Hep3B cells by endotoxin and cytokines
W Khovidhunkit, AH Moser, JK Shigenaga… - Journal of lipid …, 2001 - ASBMB
Multiple changes in HDL metabolism occur during infection and inflammation that could
potentially impair the antiatherogenic functions of HDL. Scavenger receptor class B type I
(SR-BI) promotes cholesterol efflux from peripheral cells and mediates selective uptake of
cholesteryl ester into hepatocytes, thereby playing a pivotal role in reverse cholesterol
transport. We studied the effect of endotoxin (lipopolysaccharide, LPS) and cytokines [tumor
necrosis factor (TNF) and interleukin 1 (IL-1)] on hepatic SR-BI mRNA and protein levels in …
potentially impair the antiatherogenic functions of HDL. Scavenger receptor class B type I
(SR-BI) promotes cholesterol efflux from peripheral cells and mediates selective uptake of
cholesteryl ester into hepatocytes, thereby playing a pivotal role in reverse cholesterol
transport. We studied the effect of endotoxin (lipopolysaccharide, LPS) and cytokines [tumor
necrosis factor (TNF) and interleukin 1 (IL-1)] on hepatic SR-BI mRNA and protein levels in …