[HTML][HTML] Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1
TG Vishnyakova, AV Bocharov, IN Baranova… - Journal of Biological …, 2003 - ASBMB
Scavenger receptor, class B, type I (SR-BI) mediates selective uptake of high density
lipoprotein (HDL) cholesteryl ester. SR-BI recognizes HDL, low density lipoprotein (LDL),
exchangeable apolipoproteins, and protein-free lipid vesicles containing negatively charged
phospholipids. Lipopolysaccharides (LPS) are highly glycosylated anionic phospholipids
contributing to septic shock. Despite significant structural similarities between anionic
phospholipids and LPS, the role of SR-BI in LPS uptake is unknown. Cla-1, the human SR …
lipoprotein (HDL) cholesteryl ester. SR-BI recognizes HDL, low density lipoprotein (LDL),
exchangeable apolipoproteins, and protein-free lipid vesicles containing negatively charged
phospholipids. Lipopolysaccharides (LPS) are highly glycosylated anionic phospholipids
contributing to septic shock. Despite significant structural similarities between anionic
phospholipids and LPS, the role of SR-BI in LPS uptake is unknown. Cla-1, the human SR …