Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
S Matsuyama, N Nao, K Shirato… - Proceedings of the …, 2020 - National Acad Sciences
S Matsuyama, N Nao, K Shirato, M Kawase, S Saito, I Takayama, N Nagata, T Sekizuka…
Proceedings of the National Academy of Sciences, 2020•National Acad SciencesA novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently
spreading across many countries globally. Here, we show that a TMPRSS2-expressing
VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating
and propagating SARS-CoV-2. Our results reveal that, in common with SARS-and Middle
East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently
spreading across many countries globally. Here, we show that a TMPRSS2-expressing
VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating
and propagating SARS-CoV-2. Our results reveal that, in common with SARS-and Middle
East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
National Acad Sciences