[HTML][HTML] Calnexin-dependent enhancement of nicotinic acetylcholine receptor assembly and surface expression
W Chang, MS Gelman, JM Prives - Journal of Biological Chemistry, 1997 - ASBMB
The muscle-type nicotinic acetylcholine receptor (AChR) 2 is a pentameric membrane ion
channel assembled in the endoplasmic reticulum from four homologous subunits by
mechanisms that are insufficiently understood. Nascent AChR subunits were recently found
to form complexes with the endoplasmic reticulum-resident molecular chaperone calnexin.
To determine the contribution of this interaction to AChR assembly and surface expression,
we have now used transient transfection of mouse AChR subunits and calnexin into non …
channel assembled in the endoplasmic reticulum from four homologous subunits by
mechanisms that are insufficiently understood. Nascent AChR subunits were recently found
to form complexes with the endoplasmic reticulum-resident molecular chaperone calnexin.
To determine the contribution of this interaction to AChR assembly and surface expression,
we have now used transient transfection of mouse AChR subunits and calnexin into non …