Cyclophosphamide immunosuppression does not permit successful myoblast allotransplantation in mouse
JT Vilquin, I Kinoshita, R Roy, JP Tremblay - Neuromuscular Disorders, 1995 - Elsevier
Cyclophosphamide immunosuppression does not permit successful myoblast
allotransplantation in mouse. Myoblast transplantation is a potential treatment for Duchenne
muscular dystrophy. In one clinical trial, Duchenne patients were immunosuppressed with
cyclophosphamide. We report here that myoblasts from transgenic mice expressing the β-
galactosidase reporter gene transplanted in mdx mice failed to form new muscle fibres when
cyclophosphamide (2 or 10 mg kg− 1 per day) was used for immunosuppression. At the …
allotransplantation in mouse. Myoblast transplantation is a potential treatment for Duchenne
muscular dystrophy. In one clinical trial, Duchenne patients were immunosuppressed with
cyclophosphamide. We report here that myoblasts from transgenic mice expressing the β-
galactosidase reporter gene transplanted in mdx mice failed to form new muscle fibres when
cyclophosphamide (2 or 10 mg kg− 1 per day) was used for immunosuppression. At the …