Influenza virus hemagglutinin stalk-based antibodies and vaccines
F Krammer, P Palese - Current opinion in virology, 2013 - Elsevier
Highlights•Hemagglutinin stalk-reactive monoclonal antibodies are able to neutralize
divergent influenza virus strains.•Stalk-reactive antibodies are currently being tested in
clinical studies for their potential as anti-influenza therapeutics.•Vaccine constructs based on
the conserved hemagglutinin stalk domain are able to protect mice from heterosubtypic
challenge.•Stalk-based vaccines could be further developed into human universal influenza
virus vaccines.Antibodies against the conserved stalk domain of the hemagglutinin are …
divergent influenza virus strains.•Stalk-reactive antibodies are currently being tested in
clinical studies for their potential as anti-influenza therapeutics.•Vaccine constructs based on
the conserved hemagglutinin stalk domain are able to protect mice from heterosubtypic
challenge.•Stalk-based vaccines could be further developed into human universal influenza
virus vaccines.Antibodies against the conserved stalk domain of the hemagglutinin are …
[PDF][PDF] Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies
YQ Chen, TJ Wohlbold, NY Zheng, M Huang, Y Huang… - Cell, 2018 - cell.com
Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major
mediators of protection against influenza virus infection. Here, we report that current
influenza vaccines poorly display key NA epitopes and rarely induce NA-reactive B cells.
Conversely, influenza virus infection induces NA-reactive B cells at a frequency that
approaches (H1N1) or exceeds (H3N2) that of HA-reactive B cells. NA-reactive antibodies
display broad binding activity spanning the entire history of influenza A virus circulation in …
mediators of protection against influenza virus infection. Here, we report that current
influenza vaccines poorly display key NA epitopes and rarely induce NA-reactive B cells.
Conversely, influenza virus infection induces NA-reactive B cells at a frequency that
approaches (H1N1) or exceeds (H3N2) that of HA-reactive B cells. NA-reactive antibodies
display broad binding activity spanning the entire history of influenza A virus circulation in …