Store-operated calcium entry in thrombosis and thrombo-inflammation
E Mammadova-Bach, M Nagy, JWM Heemskerk… - Cell Calcium, 2019 - Elsevier
Abstract Cytosolic free calcium (Ca 2+) is a second messenger regulating a wide variety of
functions in blood cells, including adhesion, activation, proliferation and migration. Store-
operated Ca 2+ entry (SOCE), triggered by depletion of Ca 2+ from the endoplasmic
reticulum, provides a main mechanism of regulated Ca 2+ influx in blood cells. SOCE is
mediated and regulated by isoforms of the ion channel proteins ORAI and TRP, and the
transmembrane Ca 2+ sensors stromal interaction molecules (STIMs), respectively. This …
functions in blood cells, including adhesion, activation, proliferation and migration. Store-
operated Ca 2+ entry (SOCE), triggered by depletion of Ca 2+ from the endoplasmic
reticulum, provides a main mechanism of regulated Ca 2+ influx in blood cells. SOCE is
mediated and regulated by isoforms of the ion channel proteins ORAI and TRP, and the
transmembrane Ca 2+ sensors stromal interaction molecules (STIMs), respectively. This …