CRAC channels and disease–From human CRAC channelopathies and animal models to novel drugs

S Feske - Cell calcium, 2019 - Elsevier
Abstract Ca 2+ release-activated Ca 2+(CRAC) channels are intimately linked with health
and disease. The gene encoding the CRAC channel, ORAI1, was discovered in part by
genetic analysis of patients with abolished CRAC channel function. And patients with
autosomal recessive loss-of-function (LOF) mutations in ORAI1 and its activator stromal
interaction molecule 1 (STIM1) that abolish CRAC channel function and store-operated Ca
2+ entry (SOCE) define essential functions of CRAC channels in health and disease …