[HTML][HTML] Roles of platelet STIM1 and Orai1 in glycoprotein VI-and thrombin-dependent procoagulant activity and thrombus formation
K Gilio, R van Kruchten, A Braun, A Berna-Erro… - Journal of biological …, 2010 - ASBMB
In platelets, STIM1 has been recognized as the key regulatory protein in store-operated Ca
2+ entry (SOCE) with Orai1 as principal Ca 2+ entry channel. Both proteins contribute to
collagen-dependent arterial thrombosis in mice in vivo. It is unclear whether STIM2 is
involved. A key platelet response relying on Ca 2+ entry is the surface exposure of
phosphatidylserine (PS), which accomplishes platelet procoagulant activity. We studied this
response in mouse platelets deficient in STIM1, STIM2, or Orai1. Upon high shear flow of …
2+ entry (SOCE) with Orai1 as principal Ca 2+ entry channel. Both proteins contribute to
collagen-dependent arterial thrombosis in mice in vivo. It is unclear whether STIM2 is
involved. A key platelet response relying on Ca 2+ entry is the surface exposure of
phosphatidylserine (PS), which accomplishes platelet procoagulant activity. We studied this
response in mouse platelets deficient in STIM1, STIM2, or Orai1. Upon high shear flow of …