[PDF][PDF] Interleukin-27-producing CD4+ T cells regulate protective immunity during malaria parasite infection

D Kimura, M Miyakoda, K Kimura, K Honma, H Hara… - Immunity, 2016 - cell.com
D Kimura, M Miyakoda, K Kimura, K Honma, H Hara, H Yoshida, K Yui
Immunity, 2016cell.com
Summary Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family,
which is produced by macrophages, dendritic cells, and B cells upon stimulation through
innate immune receptors. Here, we described regulatory CD4+ T cells that produce IL-27 in
response to T cell receptor stimulation during malaria infection, inhibiting IL-2 production
and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4+
T cells were Foxp3− CD11a+ CD49d+ malaria antigen-specific CD4+ T cells and were …
Summary
Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4+ T cells that produce IL-27 in response to T cell receptor stimulation during malaria infection, inhibiting IL-2 production and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4+ T cells were Foxp3CD11a+CD49d+ malaria antigen-specific CD4+ T cells and were distinct from interferon-γ (IFN-γ) producing Th1 or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-γ production by specific CD4+ T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4+ T cells and their critical role in the regulation of the protective immune response against malaria parasites.
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