[HTML][HTML] Th17-cell plasticity in Helicobacter hepaticus–induced intestinal inflammation
PJ Morrison, D Bending, LA Fouser, JF Wright… - Mucosal …, 2013 - Elsevier
Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is
associated with CD4+ T helper type 1 (Th1) and Th17 responses. However, the relative
contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient
hosts remain unknown. We report that Helicobacter hepaticus–induced typhlocolitis in
specific pathogen-free IL-10−/− mice is associated with elevated frequencies and numbers
of large intestinal interferon (IFN)-γ+ and IFN-γ+ IL-17A+ CD4+ T cells. By assessing histone …
associated with CD4+ T helper type 1 (Th1) and Th17 responses. However, the relative
contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient
hosts remain unknown. We report that Helicobacter hepaticus–induced typhlocolitis in
specific pathogen-free IL-10−/− mice is associated with elevated frequencies and numbers
of large intestinal interferon (IFN)-γ+ and IFN-γ+ IL-17A+ CD4+ T cells. By assessing histone …