Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary
LV Syro, F Rotondo, CA Serna, LD Ortiz, K Kovacs - Pituitary, 2017 - Springer
LV Syro, F Rotondo, CA Serna, LD Ortiz, K Kovacs
Pituitary, 2017•SpringerIntroduction Histologic, immunohistochemical and electron microscopic studies have
provided conclusive evidence that a marked diversity exists between tumors which secrete
growth hormone (GH) in excess. GH cell hyperplasia can also be associated with
acromegaly in patients with extrapituitary GH—releasing hormone secreting tumors or in
familial pituitary tumor syndromes. Materials and methods A literature search was performed
for information regarding pathology, GH-producing tumors and acromegaly. Results This …
provided conclusive evidence that a marked diversity exists between tumors which secrete
growth hormone (GH) in excess. GH cell hyperplasia can also be associated with
acromegaly in patients with extrapituitary GH—releasing hormone secreting tumors or in
familial pituitary tumor syndromes. Materials and methods A literature search was performed
for information regarding pathology, GH-producing tumors and acromegaly. Results This …
Introduction
Histologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH—releasing hormone secreting tumors or in familial pituitary tumor syndromes.
Materials and methods
A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly.
Results
This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary.
Conclusion
The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed.
Springer