The comet assay is widely used in human biomonitoring to measure DNA damage as a
marker of exposure to genotoxic agents or to investigate genoprotective effects. Studies
often involve small numbers of subjects, and design may be sub-optimal in other respects. In
addition, comet assay protocols in use in different laboratories vary significantly. In spite of
these difficulties, it is appropriate to carry out a pooled analysis of all available comet assay
biomonitoring data, in order to establish baseline parameters of DNA damage, and to …