miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
S He, G Zhang, H Dong, M Ma, Q Sun - OncoTargets and therapy, 2016 - Taylor & Francis
S He, G Zhang, H Dong, M Ma, Q Sun
OncoTargets and therapy, 2016•Taylor & FrancisBreast cancer is the second leading cause of cancer mortality in women worldwide.
Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203
participates in cancer cell proliferation, transformation, and apoptosis. This study showed
that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203
knockdown suppressed colony formation and transformation and also limited migration in
MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203 …
Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203
participates in cancer cell proliferation, transformation, and apoptosis. This study showed
that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203
knockdown suppressed colony formation and transformation and also limited migration in
MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203 …
Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer.
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