Time-dependent PPARγ modulation of HIF-1α signaling in hypoxic pulmonary artery smooth muscle cells

JI Blum, KM Bijli, TC Murphy, JM Kleinhenz… - The American journal of …, 2016 - Elsevier
Background Pathogenesis of pulmonary hypertension is complex and involves activation of
the transcription factor, hypoxia-inducible factor-1 (HIF-1) that shifts cellular metabolism from
aerobic respiration to glycolysis, in part, by increasing the expression of its downstream
target pyruvate dehydrogenase kinase-1 (PDK-1), thereby promoting a proliferative,
apoptosis-resistant phenotype in pulmonary vascular cells. Activation of the nuclear
hormone transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) …