[HTML][HTML] Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein β gene during adipogenesis
JW Zhang, DJ Klemm, C Vinson, MD Lane - Journal of biological chemistry, 2004 - ASBMB
The proximal promoter of the C/EBPβ gene possesses dual cis regulatory elements (TGA1
and TGA2), both of which contain core CREB binding sites. Comparison of the activities of
C/EBPβ promoter-reporter genes with 5′-truncations or site-directed mutations in the TGA
elements showed that both are required for maximal promoter function. Electrophoretic
mobility shift and chromatin immunoprecipitation (ChIP) analyses with antibodies specific to
CREB and ATF1 showed that these CREB family members associate with the proximal …
and TGA2), both of which contain core CREB binding sites. Comparison of the activities of
C/EBPβ promoter-reporter genes with 5′-truncations or site-directed mutations in the TGA
elements showed that both are required for maximal promoter function. Electrophoretic
mobility shift and chromatin immunoprecipitation (ChIP) analyses with antibodies specific to
CREB and ATF1 showed that these CREB family members associate with the proximal …