Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

C Picard, H Von Bernuth, P Ghandil, M Chrabieh… - Medicine, 2010 - journals.lww.com
Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid
differentiation factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1
receptor-mediated immunity. We documented the clinical features and outcome of 48
patients with IRAK-4 deficiency and 12 patients with MyD88 deficiency, from 37 kindreds in
15 countries.