Atypical IκB proteins in immune cell differentiation and function
M Annemann, C Plaza-Sirvent, M Schuster… - Immunology letters, 2016 - Elsevier
Abstract The NF-κB/Rel signalling pathway plays a crucial role in numerous biological
processes, including innate and adaptive immunity. NF-κB is a family of transcription factors,
whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two
distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although
the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms
remain marginally elucidated. However, work from recent years indicated that nuclear IκBs …
processes, including innate and adaptive immunity. NF-κB is a family of transcription factors,
whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two
distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although
the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms
remain marginally elucidated. However, work from recent years indicated that nuclear IκBs …