Objectives. To examine the expression of the p63 protein in normal, preneoplastic, and
neoplastic human prostatic tissue. The p63 gene, a member of the p53 gene family, is
expressed in the basal epithelial cells of multiple organs. Irregularities in p63 expression
have been associated with epithelial carcinogenesis. Methods. We performed
immunohistochemistry with an anti-p63 antibody on specimens from radical prostatectomies,
prostate needle biopsies, and metastatic prostate adenocarcinoma. We analyzed p63 …