De novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation
S Safavi, DR Robinson, S Soresi, M Carby… - The Journal of Heart and …, 2014 - Elsevier
Background Bronchiolitis obliterans syndrome (BOS) is the major cause of late graft failure
after lung transplantation. The objective was to determine whether de novo donor human
leukocyte antigen (HLA)-specific antibodies (DSA) are associated with the development of
BOS or patient survival. Data were analyzed from 188 lung transplant recipients with a follow-
up period up to 8 years. Methods HLA antibody monitoring was performed at 3-month
intervals post-transplant at routine outpatient clinic attendances and during the investigation …
after lung transplantation. The objective was to determine whether de novo donor human
leukocyte antigen (HLA)-specific antibodies (DSA) are associated with the development of
BOS or patient survival. Data were analyzed from 188 lung transplant recipients with a follow-
up period up to 8 years. Methods HLA antibody monitoring was performed at 3-month
intervals post-transplant at routine outpatient clinic attendances and during the investigation …