Targeting the checkpoint kinases: chemosensitization versus chemoprotection
BBS Zhou, J Bartek - Nature Reviews Cancer, 2004 - nature.com
BBS Zhou, J Bartek
Nature Reviews Cancer, 2004•nature.comAn important part of the cellular response to DNA damage is checkpoint activation—
checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.
Inhibiting these kinases was believed to sensitize tumour cells to cancer treatments that
damage DNA, because in the absence of checkpoints and efficient DNA repair, the
response would switch to cell death or senescence. Recent discoveries have, however,
highlighted different and expanded roles for CHK1 and CHK2, so should the therapeutic …
checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.
Inhibiting these kinases was believed to sensitize tumour cells to cancer treatments that
damage DNA, because in the absence of checkpoints and efficient DNA repair, the
response would switch to cell death or senescence. Recent discoveries have, however,
highlighted different and expanded roles for CHK1 and CHK2, so should the therapeutic …
Abstract
An important part of the cellular response to DNA damage is checkpoint activation — checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks. Inhibiting these kinases was believed to sensitize tumour cells to cancer treatments that damage DNA, because in the absence of checkpoints and efficient DNA repair, the response would switch to cell death or senescence. Recent discoveries have, however, highlighted different and expanded roles for CHK1 and CHK2, so should the therapeutic hypothesis that is concerned with targeting so-called checkpoint kinases be modified?
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