[HTML][HTML] Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

Z Xiao, Z Chen, AH Gunasekera, TJ Sowin… - Journal of Biological …, 2003 - ASBMB
UV and ionizing radiation (IR) activate DNA damage checkpoints and induce Cdc25A
degradation (Mailand, N., Falck, J., Lukas, C., Syljuasen, RG, Welcker, M., Bartek, J., and
Lukas, J.(2000) Science 288, 1425–1429; Falck, J., Mailand, N., Syljuasen, RG, Bartek, J.,
and Lukas J.(2001) Nature 410, 842–847). The degradation of Cdc25A is abrogated by
caffeine, which implicates Chk1 as the potential mediator (Mailand, N., Falck, J., Lukas, C.,
Syljuasen, RG, Welcker, M., Bartek, J., and Lukas, J.(2000) Science 288, 1425–1429) …