History of bacillus Calmette-Guerin and bladder cancer: an immunotherapy success story
HW Herr, A Morales - The Journal of urology, 2008 - Elsevier
PURPOSE: We review how the bacillus Calmette-Guerin vaccine evolved to become
standard therapy for superficial bladder cancer. MATERIALS AND METHODS: We reviewed
the historical literature describing the origin of the bacillus Calmette-Guerin vaccine as an
anticancer agent and its singular success as the most effective immunotherapy used against
a human neoplasm. RESULTS: The association between tuberculosis and cancer, and the
demonstration that bacillus Calmette-Guerin invoked immunological reactivity, inhibiting …
standard therapy for superficial bladder cancer. MATERIALS AND METHODS: We reviewed
the historical literature describing the origin of the bacillus Calmette-Guerin vaccine as an
anticancer agent and its singular success as the most effective immunotherapy used against
a human neoplasm. RESULTS: The association between tuberculosis and cancer, and the
demonstration that bacillus Calmette-Guerin invoked immunological reactivity, inhibiting …