[HTML][HTML] Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric-oxide synthase in lipopolysaccharide-stimulated macrophages
Y Jin, Y Liu, LD Nelin - Journal of Biological Chemistry, 2015 - ASBMB
The mitogen-activated protein kinases (MAPK) have been shown to participate in iNOS
induction following lipopolysaccharide (LPS) stimulation, while the role of MAPKs in the
regulation of arginase remains unclear. We hypothesized that different MAPK family
members are involved in iNOS and arginase expression following LPS stimulation. LPS-
stimulated RAW 264.7 cells exhibited increased protein and mRNA levels for iNOS,
arginase I, and arginase II; although the induction of arginase II was more robust than that …
induction following lipopolysaccharide (LPS) stimulation, while the role of MAPKs in the
regulation of arginase remains unclear. We hypothesized that different MAPK family
members are involved in iNOS and arginase expression following LPS stimulation. LPS-
stimulated RAW 264.7 cells exhibited increased protein and mRNA levels for iNOS,
arginase I, and arginase II; although the induction of arginase II was more robust than that …
