[HTML][HTML] Beyond immune cell migration: the emerging role of the sphingosine-1-phosphate receptor S1PR4 as a modulator of innate immune cell activation
C Olesch, C Ringel, B Brüne, A Weigert - Mediators of inflammation, 2017 - hindawi.com
C Olesch, C Ringel, B Brüne, A Weigert
Mediators of inflammation, 2017•hindawi.comThe sphingolipid sphingosine-1-phosphate (S1P) emerges as an important regulator of
immunity, mainly by signaling through a family of five specific G protein-coupled receptors
(S1PR1–5). While S1P signaling generally has the potential to affect not only trafficking but
also differentiation, activation, and survival of a diverse range of immune cells, the specific
outcome depends on the S1P receptor repertoire expressed on a given cell. Among the
S1PRs, S1PR4 is specifically abundant in immune cells, suggesting a major role of the …
immunity, mainly by signaling through a family of five specific G protein-coupled receptors
(S1PR1–5). While S1P signaling generally has the potential to affect not only trafficking but
also differentiation, activation, and survival of a diverse range of immune cells, the specific
outcome depends on the S1P receptor repertoire expressed on a given cell. Among the
S1PRs, S1PR4 is specifically abundant in immune cells, suggesting a major role of the …
The sphingolipid sphingosine-1-phosphate (S1P) emerges as an important regulator of immunity, mainly by signaling through a family of five specific G protein-coupled receptors (S1PR1–5). While S1P signaling generally has the potential to affect not only trafficking but also differentiation, activation, and survival of a diverse range of immune cells, the specific outcome depends on the S1P receptor repertoire expressed on a given cell. Among the S1PRs, S1PR4 is specifically abundant in immune cells, suggesting a major role of the S1P/S1PR4 axis in immunity. Recent studies indeed highlight its role in activation of immune cells, differentiation, and, potentially, trafficking. In this review, we summarize the emerging data that support a major role of S1PR4 in modulating immunity in humans and mice and discuss therapeutic implications.
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