Natural killer cells, viruses and cancer
A Cerwenka, LL Lanier - Nature reviews immunology, 2001 - nature.com
A Cerwenka, LL Lanier
Nature reviews immunology, 2001•nature.comNatural killer cells are innate immune cells that control certain microbial infections and
tumours. The function of natural killer cells is regulated by a balance between signals
transmitted by activating receptors, which recognize ligands on tumours and virus-infected
cells, and inhibitory receptors specific for major histocompatibility complex class I molecules.
Here, we review the emerging evidence that natural killer cells have an important role in vivo
in immune defence.
tumours. The function of natural killer cells is regulated by a balance between signals
transmitted by activating receptors, which recognize ligands on tumours and virus-infected
cells, and inhibitory receptors specific for major histocompatibility complex class I molecules.
Here, we review the emerging evidence that natural killer cells have an important role in vivo
in immune defence.
Abstract
Natural killer cells are innate immune cells that control certain microbial infections and tumours. The function of natural killer cells is regulated by a balance between signals transmitted by activating receptors, which recognize ligands on tumours and virus-infected cells, and inhibitory receptors specific for major histocompatibility complex class I molecules. Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence.
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