Virological features associated with the development of broadly neutralizing antibodies to HIV-1

PL Moore, C Williamson, L Morris - Trends in microbiology, 2015 - cell.com
Trends in microbiology, 2015cell.com
The development of a preventative HIV-1 vaccine remains a global public health priority.
This will likely require the elicitation of broadly neutralizing antibodies (bNAbs) able to block
infection by diverse viral strains from across the world. Understanding the pathway to
neutralization breadth in HIV-1 infected humans will provide insights into how bNAb
lineages arise, a process that probably involves a combination of host and viral factors.
Here, we focus on the role of viral characteristics and evolution in shaping bNAbs during HIV …
The development of a preventative HIV-1 vaccine remains a global public health priority. This will likely require the elicitation of broadly neutralizing antibodies (bNAbs) able to block infection by diverse viral strains from across the world. Understanding the pathway to neutralization breadth in HIV-1 infected humans will provide insights into how bNAb lineages arise, a process that probably involves a combination of host and viral factors. Here, we focus on the role of viral characteristics and evolution in shaping bNAbs during HIV-1 infection, and describe how these findings may be translated into novel vaccine strategies.
Video Abstract
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