A biphasic response of rats to cobalt
EE Roginski, W Mertz - The Journal of Nutrition, 1977 - Elsevier
The study was designed to confirm a previous, unexpected observation of a strong growth
depressing effect of 1 µg cobalt/g in rats fed lactalbumin based diets. The addition of 0.25,
0.5, and 1.0 µg of cobalt/g to the basal diet containing 0.056 µg/g depressed growth rates of
rats progressively with increasing doses. This depression was overcome by increasing the
cobalt supplement to 2 µg/g, and additional weight gain was observed with 3 µg/g. Higher
concentrations were progressively toxic. Hemoglobin concentrations, hematocrits, and …
depressing effect of 1 µg cobalt/g in rats fed lactalbumin based diets. The addition of 0.25,
0.5, and 1.0 µg of cobalt/g to the basal diet containing 0.056 µg/g depressed growth rates of
rats progressively with increasing doses. This depression was overcome by increasing the
cobalt supplement to 2 µg/g, and additional weight gain was observed with 3 µg/g. Higher
concentrations were progressively toxic. Hemoglobin concentrations, hematocrits, and …