[PDF][PDF] HIF-1: the knowns and unknowns of hypoxia sensing
A Zagórska, J Dulak - Acta Biochimica Polonica, 2004 - ruj.uj.edu.pl
A Zagórska, J Dulak
Acta Biochimica Polonica, 2004•ruj.uj.edu.plHypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that functions as a master
regulator of cellular and systemic oxygen homeostasis. It consists of two constitutively
produced subunits: HIF-1a and HIF-1b. Under normoxic conditions HIF-1a undergoes
hydroxylation at specific prolyl residues which leads to an immediate ubiquitination and
subsequent proteasomal degradation of the a subunit. Addi-
regulator of cellular and systemic oxygen homeostasis. It consists of two constitutively
produced subunits: HIF-1a and HIF-1b. Under normoxic conditions HIF-1a undergoes
hydroxylation at specific prolyl residues which leads to an immediate ubiquitination and
subsequent proteasomal degradation of the a subunit. Addi-
Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that functions as a master regulator of cellular and systemic oxygen homeostasis. It consists of two constitutively produced subunits: HIF-1a and HIF-1b. Under normoxic conditions HIF-1a undergoes hydroxylation at specific prolyl residues which leads to an immediate ubiquitination and subsequent proteasomal degradation of the a subunit. Addi-
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