[HTML][HTML] Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
G Yuan, J Nanduri, CR Bhasker, GL Semenza… - Journal of Biological …, 2005 - ASBMB
Intermittent hypoxia (IH) occurs in many pathological conditions. However, very little is
known about the molecular mechanisms associated with IH. Hypoxia-inducible factor 1 (HIF-
1) mediates transcriptional responses to continuous hypoxia. In the present study, we
investigated whether IH activates HIF-1 and, if so, which signaling pathways are involved.
PC12 cells were exposed to either to 20% O 2 (non-hypoxic control) or to 60 cycles
consisting of 30 s at 1.5% O 2, followed by 4 min at 20% O 2 (IH). Western blot analysis …
known about the molecular mechanisms associated with IH. Hypoxia-inducible factor 1 (HIF-
1) mediates transcriptional responses to continuous hypoxia. In the present study, we
investigated whether IH activates HIF-1 and, if so, which signaling pathways are involved.
PC12 cells were exposed to either to 20% O 2 (non-hypoxic control) or to 60 cycles
consisting of 30 s at 1.5% O 2, followed by 4 min at 20% O 2 (IH). Western blot analysis …