[HTML][HTML] Transforming growth factor β1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression

S McMahon, M Charbonneau, S Grandmont… - Journal of Biological …, 2006 - ASBMB
The hypoxia-inducible transcription factor-1 (HIF-1) is central to a number of pathological
processes through the induction of specific genes such as vascular endothelial growth factor
(VEGF). Even though HIF-1 is highly regulated by cellular oxygen levels, other elements of
the inflammatory and tumor microenvironment were shown to influence its activity under
normal oxygen concentration. Among others, recent studies indicated that transforming
growth factor (TGF) β increases the expression of the regulatory HIF-1α subunit, and induces …