[HTML][HTML] Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
T Ishii, K Itoh, S Takahashi, H Sato, T Yanagawa… - Journal of Biological …, 2000 - ASBMB
Electrophiles and reactive oxygen species have been implicated in the pathogenesis of
many diseases. Transcription factor Nrf2 was recently identified as a general regulator of
one defense mechanism against such havoc. Nrf2 regulates the inducible expression of a
group of detoxication enzymes, such as glutathione S-transferase and NAD (P) H: quinone
oxidoreductase, via antioxidant response elements. Using peritoneal macrophages from
Nrf2-deficient mice, we show here that Nrf2 also controls the expression of a group of …
many diseases. Transcription factor Nrf2 was recently identified as a general regulator of
one defense mechanism against such havoc. Nrf2 regulates the inducible expression of a
group of detoxication enzymes, such as glutathione S-transferase and NAD (P) H: quinone
oxidoreductase, via antioxidant response elements. Using peritoneal macrophages from
Nrf2-deficient mice, we show here that Nrf2 also controls the expression of a group of …