[HTML][HTML] Mitochondrial Ca2+ uptake and release influence metabotropic and ionotropic cytosolic Ca2+ responses in rat oligodendrocyte progenitors
PB Simpson, JT Russell - The Journal of Physiology, 1998 - ncbi.nlm.nih.gov
PB Simpson, JT Russell
The Journal of Physiology, 1998•ncbi.nlm.nih.govMany physiologically important activities of oligodendrocyte progenitor cells (O-2A cells),
including proliferation, migration and differentiation, are regulated by cytosolic Ca 2+
signals. However, little is known concerning the mechanisms of Ca 2+ signalling in this cell
type. We have studied the interactions between Ca 2+ entry, Ca 2+ release from
endoplasmic reticulum and Ca 2+ regulation by mitochondria in influencing cytosolic Ca 2+
responses in O-2A cells.
including proliferation, migration and differentiation, are regulated by cytosolic Ca 2+
signals. However, little is known concerning the mechanisms of Ca 2+ signalling in this cell
type. We have studied the interactions between Ca 2+ entry, Ca 2+ release from
endoplasmic reticulum and Ca 2+ regulation by mitochondria in influencing cytosolic Ca 2+
responses in O-2A cells.
Abstract
1. Many physiologically important activities of oligodendrocyte progenitor cells (O-2A cells), including proliferation, migration and differentiation, are regulated by cytosolic Ca 2+ signals. However, little is known concerning the mechanisms of Ca 2+ signalling in this cell type. We have studied the interactions between Ca 2+ entry, Ca 2+ release from endoplasmic reticulum and Ca 2+ regulation by mitochondria in influencing cytosolic Ca 2+ responses in O-2A cells.
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