Cerebral white matter injury of the premature infant—more common than you think
JJ Volpe - Pediatrics, 2003 - publications.aap.org
Brain injury in the premature infant consists of multiple lesions, principally germinal
matrixintraventricular hemorrhage, posthemorrhagic hydrocephalus, and periventricular
leukomalacia (PVL). The last of these now appears to be the most important determinant of
the neurologic morbidity observed in survivors of birth weight 1500 g. Indeed, of these very
low birth weight infants, 10% later exhibit cerebral palsy, and 50%, cognitive and behavioral
deficits. 1–5 The focal necrotic lesions of PVL deep in the cerebral white matter correlate …
matrixintraventricular hemorrhage, posthemorrhagic hydrocephalus, and periventricular
leukomalacia (PVL). The last of these now appears to be the most important determinant of
the neurologic morbidity observed in survivors of birth weight 1500 g. Indeed, of these very
low birth weight infants, 10% later exhibit cerebral palsy, and 50%, cognitive and behavioral
deficits. 1–5 The focal necrotic lesions of PVL deep in the cerebral white matter correlate …