Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology
D Zecher, Q Li, AL Williams, JT Walters… - Transplant …, 2012 - Elsevier
BACKGROUND: Acute allograft rejection is dependent on adaptive immunity, but it is
unclear whether the same is true for chronic rejection. Here we asked whether innate
immunity alone is sufficient for causing chronic rejection of mouse cardiac allografts.
METHODS: We transplanted primarily vascularized cardiac grafts to recombinase activating
gene-knockout (RAG−/−) mice that lack T and B cells but have an intact innate immune
system. Recipients were left unmanipulated, received adjuvants that stimulate innate …
unclear whether the same is true for chronic rejection. Here we asked whether innate
immunity alone is sufficient for causing chronic rejection of mouse cardiac allografts.
METHODS: We transplanted primarily vascularized cardiac grafts to recombinase activating
gene-knockout (RAG−/−) mice that lack T and B cells but have an intact innate immune
system. Recipients were left unmanipulated, received adjuvants that stimulate innate …