Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras
JS Oh, JJ Kim, JY Byun, IA Kim - International Journal of Radiation …, 2010 - Elsevier
PURPOSE: To evaluate the potential of targeting Lin28-let7 microRNA regulatory network
for overcoming the radioresistance of cancer cells having activated K-Ras signaling.
METHODS AND MATERIALS: A549 lung carcinoma cells and ASPC1 pancreatic cancer
cells possessing K-RAS mutation were transfected with pre-let7a microRNA or Lin28 siRNA,
respectively. Clonogenic assay, quantitative reverse transcription polymerase chain
reaction, and Western analysis were performed. The effects of Lin28 on SQ20B cells having …
for overcoming the radioresistance of cancer cells having activated K-Ras signaling.
METHODS AND MATERIALS: A549 lung carcinoma cells and ASPC1 pancreatic cancer
cells possessing K-RAS mutation were transfected with pre-let7a microRNA or Lin28 siRNA,
respectively. Clonogenic assay, quantitative reverse transcription polymerase chain
reaction, and Western analysis were performed. The effects of Lin28 on SQ20B cells having …