A combined deficiency of tissue factor and PAR-4 is associated with fatal pulmonary hemorrhage in mice
MF Bode, N Mackman - Thrombosis research, 2016 - Elsevier
Introduction Mice with a complete absence of tissue factor (TF) die during embryonic
development whereas mice with low levels of TF (Low-TF mice) survive to adulthood. Low-
TF mice exhibit spontaneous hemorrhage in various organs, including the lung. In contrast,
mice can survive without protease-activated receptor (PAR)-4, which is the major thrombin
receptor on mouse platelets. We determined the effect of combining a deficiency PAR-4
(primary hemostasis) with a deficiency in TF (secondary hemostasis) on embryonic …
development whereas mice with low levels of TF (Low-TF mice) survive to adulthood. Low-
TF mice exhibit spontaneous hemorrhage in various organs, including the lung. In contrast,
mice can survive without protease-activated receptor (PAR)-4, which is the major thrombin
receptor on mouse platelets. We determined the effect of combining a deficiency PAR-4
(primary hemostasis) with a deficiency in TF (secondary hemostasis) on embryonic …