[HTML][HTML] Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber …
Cardiac chamber morphogenesis requires the coordinated growth of both cardiac muscle
and endocardial cell lineages. Paracrine growth factors may modulate the coordinated
cellular specification and differentiation during cardiac chamber morphogenesis, as
suggested by the essential role of endothelial-derived growth factors, neuregulin-1, and
insulin-like growth factor-I. Using the whole mouse embryo culture system for delivery of
diffusible factors into the cardiac chamber, neuregulin-1 was shown to promote trabeculation …
and endocardial cell lineages. Paracrine growth factors may modulate the coordinated
cellular specification and differentiation during cardiac chamber morphogenesis, as
suggested by the essential role of endothelial-derived growth factors, neuregulin-1, and
insulin-like growth factor-I. Using the whole mouse embryo culture system for delivery of
diffusible factors into the cardiac chamber, neuregulin-1 was shown to promote trabeculation …