Prognostic parameters for flare in systemic lupus erythematosus
MJ Mirzayan, RE Schmidt, T Witte - Rheumatology, 2000 - academic.oup.com
MJ Mirzayan, RE Schmidt, T Witte
Rheumatology, 2000•academic.oup.comObjective. To characterize prognostic parameters for systemic lupus erythematosus (SLE)
flares. Methods. In a prospective study, 120 SLE patients attending our out‐patient clinic
were evaluated every 3 months for 2 yr. At every visit clinical manifestations and laboratory
parameters were assessed and the SLE disease activity index (SLEDAI) was determined. A
correlation analysis of the number of flares in the first year and SLEDAI as a marker of
disease activity after 1 and 2 yr with several parameters determined at the start of the study …
flares. Methods. In a prospective study, 120 SLE patients attending our out‐patient clinic
were evaluated every 3 months for 2 yr. At every visit clinical manifestations and laboratory
parameters were assessed and the SLE disease activity index (SLEDAI) was determined. A
correlation analysis of the number of flares in the first year and SLEDAI as a marker of
disease activity after 1 and 2 yr with several parameters determined at the start of the study …
Abstract
Objective. To characterize prognostic parameters for systemic lupus erythematosus (SLE) flares.
Methods. In a prospective study, 120 SLE patients attending our out‐patient clinic were evaluated every 3 months for 2 yr. At every visit clinical manifestations and laboratory parameters were assessed and the SLE disease activity index (SLEDAI) was determined. A correlation analysis of the number of flares in the first year and SLEDAI as a marker of disease activity after 1 and 2 yr with several parameters determined at the start of the study was performed.
Results. Flares were predicted by erythrocyte sedimentation rate (P=0.001), anaemia (P=0.006) and lymphopenia (P=0.005). The SLEDAI after 1 yr was predicted by the titre of antinuclear antibodies (P=0.009), antibodies against double‐stranded DNA (P=0.007), lymphopenia (P=0.007), anaemia (P=0.0002) and SLEDAI determined at the start of the study (P=0.001).
Conclusions. Anaemia and lymphopenia predict both flares and SLEDAI within the next year of follow‐up.
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