[HTML][HTML] Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways
TA Rouault, N Maio - Journal of Biological Chemistry, 2017 - ASBMB
Fe-S cofactors are composed of iron and inorganic sulfur in various stoichiometries. A
complex assembly pathway conducts their initial synthesis and subsequent binding to
recipient proteins. In this minireview, we discuss how discovery of the role of the mammalian
cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characterization of
the function of its Fe-S cluster in sensing and regulating cellular iron homeostasis. Moreover,
we present an overview of recent studies that have provided insights into the mechanism of …
complex assembly pathway conducts their initial synthesis and subsequent binding to
recipient proteins. In this minireview, we discuss how discovery of the role of the mammalian
cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characterization of
the function of its Fe-S cluster in sensing and regulating cellular iron homeostasis. Moreover,
we present an overview of recent studies that have provided insights into the mechanism of …