[HTML][HTML] Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor …
AD Nguyen, JG McDonald, RK Bruick… - Journal of Biological …, 2007 - ASBMB
Endoplasmic reticulum-associated degradation of the enzyme 3-hydroxy-3-methylglutaryl-
CoA reductase represents one mechanism by which cholesterol synthesis is controlled in
mammalian cells. The key reaction in this degradation is binding of reductase to Insig
proteins in the endoplasmic reticulum, which is stimulated by the cholesterol precursor
lanosterol. Conversion of lanosterol to cholesterol requires removal of three methyl groups,
which consumes nine molecules of dioxygen. Here, we report that oxygen deprivation …
CoA reductase represents one mechanism by which cholesterol synthesis is controlled in
mammalian cells. The key reaction in this degradation is binding of reductase to Insig
proteins in the endoplasmic reticulum, which is stimulated by the cholesterol precursor
lanosterol. Conversion of lanosterol to cholesterol requires removal of three methyl groups,
which consumes nine molecules of dioxygen. Here, we report that oxygen deprivation …