BACKGROUND: We conducted a meta-analysis of gray matter abnormalities in bipolar
disorder (BD) using voxel-based morphometry studies to help clarify the structural
abnormalities underpinning this condition. METHODS: A systematic review was conducted
for voxel-based morphometry studies of patients with BD. Meta-analyses of gray matter
differences between BD and control subjects were undertaken using “signed differential
mapping,” a novel method that, in contrast to previously used techniques, allows inclusion of …