[HTML][HTML] A randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive-compulsive disorder: clinical and …
Background Deep brain stimulation (DBS) is an emerging treatment for severe obsessive-
compulsive disorder (OCD). We compared the efficacy of ventral capsule/ventral striatal
(VC/VS) and anteromedial subthalamic nucleus (amSTN) DBS in the same patients and
tested for mechanistic differences on mood and cognitive flexibility and associated neural
circuitry. The possible synergistic benefit of DBS at both sites and cognitive behavioral
therapy was explored. Methods Six patients with treatment-refractory OCD (5 men; Yale …
compulsive disorder (OCD). We compared the efficacy of ventral capsule/ventral striatal
(VC/VS) and anteromedial subthalamic nucleus (amSTN) DBS in the same patients and
tested for mechanistic differences on mood and cognitive flexibility and associated neural
circuitry. The possible synergistic benefit of DBS at both sites and cognitive behavioral
therapy was explored. Methods Six patients with treatment-refractory OCD (5 men; Yale …