• Eleven patients who developed manic syndromes after brain injury (secondary mania)
were studied. Six patients had depressive episodes before mania and five had a definite or
possible family history of affective disorder. Eight had lesions involving limbic areas, and
nine had right hemisphere involvement. In addition to focal brain injury, mean values for
bifrontal and third ventricle/brain ratios of manic patients were significantly increased when
compared with non-manic patients who had lesions matched for cause, location, volume …